Beilstein J. Org. Chem.2021,17, 245–272, doi:10.3762/bjoc.17.25
reaction of 54 with AlCl3 and an alkene at −20 °C (Scheme 22). The difluorocyclopropane 55 was obtained in 75% yield [63].
A bis(trifluoromethyl)zinc reagent was employed as the difluorocarbene source for the gem-difluorocyclopropanation of alkenes or alkynes via thermal decomposition [64]. The reagent was
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Graphical Abstract
Scheme 1:
Synthesis of 1,1-difluoro-2,3-dimethylcyclopropane (2).
Beilstein J. Org. Chem.2013,9, 2404–2409, doi:10.3762/bjoc.9.277
.
Keywords: organo-fluorine; Ruppert–Prakash reagent; trifluoromethyl; trifluoromethylation; trifluoromethylzinc; Introduction
Organo-fluorine compounds have received considerable attention in the fields of biomedical chemistry, agrochemistry, and organic material science due to their unique chemical
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Graphical Abstract
Figure 1:
Copper-catalyzed trifluoromethylation of various aryl iodides. Yields were determined by 19F NMR an...